Projekt 6

Effects of DBS on Speech and Language Functions

With this project we strive to analyze the effect of Deep Brain Stimulation (DBS) on language and speech functions. This is pursued against the background of frequently reported adverse effects of DBS on language and speech as well as in regard of the controversially discussed conceptualization of subcortical language processing. In order to comprehensively describe biolinguistic functions, we examine patients with different neurological movement disorders treated with DBS of distinct target areas. By applying neurophysiological, psychometrical and behavioral methods two complementary approaches are followed. The first encompasses the examination of patients accomplishing a variety of language and speech tasks under active versus inactive DBS. Secondly, deep brain recordings are performed directly from the target areas of DBS immediately after the implantation. Thus the role of basal ganglia and thalamic regions in language related processes can be investigated by measuring changes of neural activation during task performance.

Aiming at a further optimization of DBS therapy the project is accomplished in close cooperation with project 3, 8 and 9 of the clinical research group.

Priv. Doz. Dr. Fabian Klostermann, Principal Investigator
Charité – Campus Benjamin Franklin
Department of Neurology / AG Motorik und Kognition
Hindenburgdamm 30
12203 Berlin
Tel.: +49-30-8445 2017
Fax: +49-30-8445 4264
E-mail: fabian.klostermann@charite.de

Prof. Dr. phil., Dipl.-Psych. Angela D. Friederici, Principal Investigator
Max Planck Institute for Human Cognitive and Brain Sciences
Department of Neuropsychology

Stephanstraße 1a
04103 Leipzig
Tel.: +49-341-9940 112
Fax: +49-341-9940 113
E-mail: angelafr@cbs.mpg.de

Dr. Felicitas Ehlen, Postdoc
Charité – Campus Benjamin Franklin
Department of Neurology
Hindenburgdamm 30
12203 Berlin
Tel.: +49-30-450-560 234 / +49-30-8445-2397
E-Mail: felicitas.ehlen@charite.de