Project 4

Abstract
In the first funding period, we developed a computational model of basal ganglia pathways that is capable of stimulus-response learning via reinforcements. Applying our model to the study of basal ganglia dysfunctions in Parkinson’s disease, we proposed that Parkinsonian motor symptoms result from increased decision conflict between direct, indirect and hyperdirect basal ganglia pathways (Schroll, Vitay, & Hamker, 2014). In an EEG study in cooperation with Rolf Verleger at the University of Lübeck, we found empirical evidence for increased decision conflict in Parkinsonian patients (Verleger, Schroll, & Hamker, 2013).
During the second funding period, we have been investigating the role of beta oscillations in reinforcement learning. We develop a spiking version of our computational model that allows investigating neuronal oscillations within the basal ganglia during stimulus-response learning. The model is used to explore potential generators of beta activity within the basal ganglia and to develop hypotheses on the functions of beta activity in learning and motor responding. In addition, we record local field potentials in patients with Parkinson’s disease to investigate potential influences of dopamine on beta activity.

Prof. Dr. rer. nat. John-Dylan Haynes, Principal Investigator
Charité – Campus Mitte
Bernstein Center for Computational Neuroscience
Haus 6, Philippstrasse 13
10115 Berlin
Tel.: +49-30-2093 6762
Fax: +49-30-2093 6769
Email: haynes@bccn-berlin.de
Prof. Dr. Ing. Fred Hamker, Principal Investigator
Chemnitz University of Technology
Department of Computer Science / Professor for Artificial Intelligence
Straße der Nationen 62
09107 Chemnitz
Tel.: +49-371-5313 7875
Fax: +49-371-5312 5739
Email: fred.hamker@informatik.tu-chemnitz.de
Prof. Dr. Andrea Kühn, Principal Investigator
Charité – Campus Virchow Klinikum
Department of Neurology / AG Bewegungsstörungen
Augustenburger Platz 1
13353 Berlin
Tel.: +49-30-450 560 123 (Sekretariat)
Fax: +49-30-450 560 901
Email: andrea.kuehn@charite.de
Dr. rer. nat. Marco Rusconi, Postdoc
Charité – Campus Mitte
Bernstein Center for Computational Neuroscience
Haus 6, Philippstrasse 13
10115 Berlin
Email: marco.rusconi@bccn-berlin.de
Henning Schroll, PhD
Charité – Campus Mitte
Bernstein Center for Computational Neuroscience

Haus 6, Philippstrasse 13
10115 Berlin
Email: henning.schroll@uni-muenster.de