Project 11

Mechanisms of pathological oscillations in the cortico-basal ganglia loop and its modulation by deep brain stimulation in the 6-OHDA rat model of Parkinson´s disease

In Parkinson´s disease (PD), the chronic progressive loss of dopaminergic neurons of the substantia nigra compacta disrupts signal processing in the cortico-basal ganglia loop. The dynamics of the emergence of pathological network interactions, the modulation of pathological signals by deep brain stimulation and the correlation with disease symptoms remain incompletely understood.
The main focus of our project is the elctrophysiological analysis of pathological network interactions in PD, with a special emphasis on network changes in subjects suffering from levodopa-induced dyskinesias. We will combine in vivo electrophysiology in awake freely moving subjects with in vitro slice elctrophysiology to be able to understand disease mechanisms from the single cell to the network level.

Dr. med. Christoph van Riesen, Principal Investigator
Charité – Campus Virchow Klinikum
Department of Neurology / AG Bewegungsstörungen
Augustenburger Platz 1
13353 Berlin
Tel.: +49-30-450 525 194
Fax: +49-30-450 525 919
E-mail: christoph.van-riesen@charite.de
Prof. Dr. rer. nat. Jörg Geiger, Principal Investigator
Charite – Campus Mitte
Neurophysiological Institute
Chariteplatz 1
10117 Berlin
Tel.: +49-30-450539730
Fax.: +49-30-450539950
E-mail: joerg.geiger@charite.de
Jens-Kersten Haumesser, Investigator
E-Mail: jens-kersten.haumesser@charite.de
Nele Elisa Bubel, PhD Student
E-Mail: nele-elisa.bubel@charite.de