In January 2014 the DFG referee board decided in favour of the Clinical Research Unit 247 and granted another three years of funding. Based on our findings in the first funding period, during the next three years we will continue to explore the mechanisms of action of DBS and cortex basal ganglia neurophysiology. We will strengthen our neurophysiological focus with two new projects. In Project 11 we aim to elucidate how pathological oscillations evolve in space and time and correlate with clinical behaviour in a 6-OHDA mouse model. A new prototype of DBS impulse generator will be used in Project 12. This novel device will be able to stimulate and record LFP activity from the target area at the same time. In Project 12 we will explore LFP signals from target area and identify the most suitable LFP parameters to enable closed-loop DBS for a better treatment outcome.